Some heavy users even begin to develop Cannabis Emesis Syndrome, which is characterized by nausea and vomiting while stoned. “Very heavy frequent use will down-regulate cannabinoid receptors, making the body less adaptive to stress and changing neuroendocrine environments,” explains Joseph Morgan, a physician and medical expert for the cannabis education platform Green Flower Media. This can also lead to increased anxiety, because it may prevent the endocannabinoid system from working to maintain balance. “Tolerance happens when the cannabinoid receptors detect too much THC over time, causing the receptors to withdraw into the cells, basically ‘hiding’ from the THC in the bloodstream,” she explains. The most common change people see is simply increased tolerance to THC, the compound in cannabis that makes you feel high, which results in less intense effects, says Bonni Goldstein, physician, and medical director of Canna-Centers Wellness and Education, which offers potential cannabis patients medical evaluations. Christopher Klein, a 32-year-old working in gym sales in Austin, says that after a decade of consistent use, cannabis no longer helps him sleep like it used to. “It ranges from ‘nothing’s changed’ to people experiencing full-blown panic attacks and increased anxiety out of the blue.”Įvidently, the changes people experience in their reaction to weed aren’t always positive. “I have heard from many patients and colleagues about this phenomenon of cannabis affecting them differently over the years,” says Nikola Djordjevic, physician and medical advisor for the online cannabis guide LoudCloudHealth. It turns out weed can actually have a different effect on us as we age. Why does weed suddenly like me? I wondered. A few weeks later, a friend offered me a few puffs of a very high-THC strain, which I expected would send me back into my old thought patterns - but it actually just made me feel happy and creatively inspired. It actually didn't make me anxious at all. Then, at age 29, I tried a low-THC strain, knowing it might be less likely to cause anxiety. All of them would send me into a paranoid thought-loop. I experimented with different strains, from indica to sativa and different forms, from joints to edibles. Throughout my 20s, I tried weed only a handful of times.
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